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KMID : 0371319920430040489
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Journal of the Korean Surgical Society
1992 Volume.43 No. 4 p.489 ~ p.497
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Role of T-lymphocyte in the Heart-lung Transplanted Mouse
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정대윤
한덕종/윤대원/배수동/강구/이인철
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Abstract
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Cell mediated Immunity acts as a major role in organ transplantation.
We performed the heart-lung transplantation in mice in order to compare the phenotypic change of splenocyte and lymphocyte infictrated into the functional change of splenocyte.
After heterotopic heart-lung grafts from DBA(H-2d) donors to CBA(H-2k) mice, the mean graft survival was 15.2 days. In sequential immunohistochemical analysis of the spleen, there was no decisive difference of T cell subpopulation in the white
pulp
of
during the immediate postoperative period. Contrary to the insignificant response of T. cells, the population of T cells in the red pulp of the spleen increased from posttransplant 2nd day and decreased from posttransplant 6th day. Above result
was
consistent with the result of cytotoxicity of splenocyte, which showed increased level from postoperative 4th day to 8th day and decreased thereafter.
The population of lymphocytes infiltrated into the graft increased maximally at posttransplant 5th day and 6th day. The population of T cells increased from posttransplant 2nd day showed the maximal level at 6th day. On the contrary. T cells
increased
from the posttransplant 3rd day but to the lesser extent than the T cells.
These results show that there was a positive correlation of phenotypic and funtional change of splenic T cells in immediate postoperative period. Furthermore T cell infilatrated into the graft depicted the higher level than the T cell and peak
response
in postoperative 6th day illustrating the crucial role of T cell in the effector limb of rejection.
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KEYWORD
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